Technical Art of Science


AnnonaSense CLR™

AnnonaSense CLR is a neurocosmetic active ingredient obtained from the upcycled part of Annona cherimola, an edible fruit originating from South America. AnnonaSense CLR effectively  provides the skin with means to establish a sustainable homeostatic balance, improving skin health and well-being. A neurocosmetic active ingredient, AnnonaSense CLR acts at the top of the hierarchy of the skin’s immune system.

As an agonist for the CB2 receptor it reduces TRPV1-induced and other inflammatory processes. AnnonaSense CLR™ has a strong influence on the entire skin-brain-endocrine feedback loop. Histamine, as well as TNFα/Substance P-induced stress is down-regulated and the expression of a vital detrimental receptor in skin, IL-31RA is decreased. AnnonaSense CLR makes the skin less sensitive and more balanced, even itch is perceivably reduced. It perceivably improves the look and comfort of skin and it reduces psychological stress and improves quality of sleep. Consequentially, it reduces the production of cortisol inside the body and, lastly and making this loop complete, it acts against the negative effects of systemic cortisol on skin by improving skin health.

• Expands the body’s natural capacity to handle stress
• Reduces cortisol in the body
• Reduces skin redness, itch and sensitivity
• Global compliant CBD alternative

Annona Cherimola Fruit Extract
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